barrett esophagus

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	176
interventional	111
Observational	57
Registry	8

Studies over Time by Start Date

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Interventional Trials

Intervention Type

intervention_type	Study_Count
Device	41
Drug	21
Procedure	19
Device|Procedure	5
Drug|placebo	5
Diagnostic Test	4
Other	4
Device|Other	3
Other|Procedure	2
Behavioral	1
Device|Drug	1
Device|Other|Procedure	1
Diagnostic Test|Drug	1
Drug|Other	1
Drug|Other|placebo	1
Drug|Procedure	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
United States	66
NA	6
United Kingdom	5
France	4
Netherlands	4
Germany	3
Sweden	3
United States|Netherlands	2
United States|United Kingdom	2
Australia|Belgium|Germany|Netherlands|Switzerland|United Kingdom	1
Austria	1
Brazil	1
China	1
Czechia	1
Greece	1
Mexico	1
Singapore	1
Spain	1
United States|Canada	1
United States|Canada|Puerto Rico	1
United States|France|Germany	1
United States|France|United Kingdom	1
United States|Germany	1
United States|Puerto Rico	1
United States|Spain	1

Sites per Study

Site_count	Study_Count
1	72
2	9
3	5
4	4
5	8
6	1
7	2
8	1
10	3
11	1
12	2
14	1
19	1
28	1

Phase

Phase	Study_Count
N/A	73
Phase 2	13
Phase 1	8
Phase 4	7
Early Phase 1	6
Phase 3	2
Phase 1/Phase 2	1
Phase 2/Phase 3	1

Number of Arms

Number_of_Arms	Count_of_Studies
1	54
2	40
3	6
4	4
5	1
NA	6

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	8.0	1.0000	16	50	20.00000	208	46.0	7.00000
1st Qu.	27.0	30.0000	18	50	33.00000	208	54.5	31.00000
Median	31.5	76.0000	23	50	66.50000	208	63.0	50.00000
Mean	29.0	241.9863	30	50	73.33333	208	63.0	52.71429
3rd Qu.	36.0	150.0000	34	50	105.50000	208	71.5	80.00000
Max.	40.0	5521.0000	60	50	152.00000	208	80.0	90.00000

Trial Group Type

group_type	Group_Count
Experimental	88
Active Comparator	51
Other	17
No Intervention	8
NA	6
Placebo Comparator	5
Sham Comparator	4

Intervention Model

intervention_model	Study_Count
Single Group Assignment	61
Parallel Assignment	35
Crossover Assignment	12
NA	2
Sequential Assignment	1

Primary Purpose

primary_purpose	Study_Count
Treatment	41
Diagnostic	30
Prevention	12
Screening	11
Basic Science	7
Device Feasibility	4
Other	4
Health Services Research	1
NA	1

Observational Studies

Studies by Country

Country	Study_Count
United States	46
United States|Netherlands	2
Australia	1
Belgium	1
Belgium|Canada|France|Luxembourg	1
France	1
Ireland	1
NA	1
United Kingdom	1
United States|Canada	1
United States|Netherlands|United Kingdom	1

Sites per Study

Site_count	Study_Count
1	41
2	5
3	2
4	3
6	2
8	1
10	2
20	1

Enrollment Metrics

Measure	Observational
Min	10.000
1st Qu	60.000
Median	125.000
Mean	1745.825
3rd Qu	300.000
Max	75000.000

Observation Model

observational_model	Study_Count
Cohort	36
Case-Only	8
Case-Control	7
Case Control	2
Other	2
NA	2

Time Perspective

time_perspective	Study_Count
Prospective	40
Cross-Sectional	8
Retrospective	5
Other	2
NA	2

Registries

Studies by Country

Country	Study_Count
United States	5
Austria	1
France	1
United States|Belgium|Canada|Germany|Netherlands|United Kingdom	1

Sites per Study

Site_count	Study_Count
1	6
13	1
16	1

Enrollment Metrics

Measure	Registries
Min	150.00
1st Qu	287.00
Median	625.00
Mean	12870.75
3rd Qu	3250.00
Max	90000.00

Registry Model

observational_model	Study_Count
Cohort	5
Case-Only	2
Case Control	1

Time Perspective

time_perspective	Study_Count
Prospective	8

Follow-up

target_duration	Study_Count
5 Years	5
10 Years	1
3 Years	1
30 Days	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT04316975	Utility Of Mutational Load As A Predictor For Endoscopic Treatment Response In Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT04316975	Recruiting	University of North Carolina, Chapel Hill	2021-03-31
NCT03366012	Rapid Assessment of Esophageal Adenocarcinoma Risk Test	https://ClinicalTrials.gov/show/NCT03366012	Enrolling by invitation	Columbia University	2021-08-31
NCT03278327	Impact of an Endoscopic Treatment of the Line Z on the Gastronomic Recurrence and the Gastro- Esophageal Reflux Disease in the Care of the Adenocarcinoma of Barrett’s Oesophagus	https://ClinicalTrials.gov/show/NCT03278327	Recruiting	Institut Paoli-Calmettes	2019-06-30
NCT03240679	Endoscopic Mucosal Resection and Cellular Matrix	https://ClinicalTrials.gov/show/NCT03240679	Enrolling by invitation	Mayo Clinic	2022-04-01
NCT03222635	Prospective Endoscopic Follow-up of Patients With Submucosal Esophageal Adenocarcinoma (The PREFER Trial)	https://ClinicalTrials.gov/show/NCT03222635	Recruiting	Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)	2025-07-25
NCT03193216	The Impact of Adjuvant Liquid Alginate on Endoscopic Ablation Therapy of Complicated Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT03193216	Active, not recruiting	Medical University of South Carolina	2022-06-30
NCT03120195	EndoRotor® Ablation of Barrett’s Esophagus: Safety and Feasibility Study	https://ClinicalTrials.gov/show/NCT03120195	Completed	Foundation for Liver Research	2019-01-21
NCT03097666	Evaluation of Safety and Dose Response Using C2 CryoBalloonâ„¢ Swipe Ablation System for Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT03097666	Active, not recruiting	C2 Therapeutics, Inc.	2018-11-01
NCT03077594	Characterization of the Neo-squamous Epithelial Barrier	https://ClinicalTrials.gov/show/NCT03077594	Recruiting	Mayo Clinic	2020-09-30
NCT03073226	A Prospective Study Comparing the Accuracy of Olympus Lucera Spectrum Technology vs Olympus Lucera Elite Technology in the in Vivo Diagnosis of Barrett’s Oesophagus and Colorectal Polyps: The ELITE Study	https://ClinicalTrials.gov/show/NCT03073226	Completed	Portsmouth Hospitals NHS Trust	2017-11-30
NCT02994693	Natural History of Barrett’s Esophagus Using Tethered Capsule Endomicroscopy	https://ClinicalTrials.gov/show/NCT02994693	Recruiting	Massachusetts General Hospital	2023-12-31
NCT02947971	Pilot Study for TCE Imaging of the Esophagus Using an OFDI Capsule With a Compact Imaging System	https://ClinicalTrials.gov/show/NCT02947971	Recruiting	Massachusetts General Hospital	2020-09-30
NCT02922049	pCLE in the Detection of Esophageal and Gastric Lesions and Intestinal Metaplasia or Dysplasia in Patients After Endoscopic Treatment of BORN	https://ClinicalTrials.gov/show/NCT02922049	Completed	Institute for Clinical and Experimental Medicine	2019-04-30
NCT02890979	Swallowable Sponge Cell Sampling Device and Next Generation Sequencing in Detecting Esophageal Cancer in Patients With Low or High Grade Dysplasia, Barrett Esophagus, or Gastroesophageal Reflux Disease	https://ClinicalTrials.gov/show/NCT02890979	Active, not recruiting	OHSU Knight Cancer Institute	2020-12-31
NCT02879721	Expression and Function of the Renin-Angiotensin System in the Esophagus	https://ClinicalTrials.gov/show/NCT02879721	Completed	Göteborg University	2012-12-31
NCT02864043	Barrett’s Dysplasia Detection Pilot Trial Using the NvisionVLE® Imaging System	https://ClinicalTrials.gov/show/NCT02864043	Active, not recruiting	NinePoint Medical	2020-06-01
NCT02852525	Confocal Laser Probe to Treat Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT02852525	Completed	Ochsner Health System	2015-12-31
NCT02729948	Tethered Capsule Endoscope in Screening Patients With Barrett Esophagus	https://ClinicalTrials.gov/show/NCT02729948	Completed	University of Washington	2017-08-03
NCT02688114	Healing of the Esophageal Mucosa After RFA of Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT02688114	Enrolling by invitation	Dallas VA Medical Center	2020-05-31
NCT01733147	Modulation of Esophageal Inflammation in Barrett’s Esophagus by Omega-3 Fatty Acids	https://ClinicalTrials.gov/show/NCT01733147	Active, not recruiting	Mayo Clinic	2021-01-31
NCT02560623	Minimally-Invasive Detection of Barrett’s Esophagus and Barrett’s Esophagus Related Dysplasia/Carcinoma	https://ClinicalTrials.gov/show/NCT02560623	Recruiting	Mayo Clinic	2020-12-31
NCT03388047	Feasibility of Multi-Spectral Endoscopic Imaging for Detection of Early Neoplasia in Barrett’s Oesophagus	https://ClinicalTrials.gov/show/NCT03388047	Recruiting	University of Cambridge	2020-12-31
NCT02549053	Prevalence of Human Papillomavirus in Barrett Esophagus Compared With Controls	https://ClinicalTrials.gov/show/NCT02549053	Completed	University Hospital, Angers	2015-02-28
NCT02534233	Evaluation of Effect of CryoBalloon Focal Ablation System on Human Esophageal Epithelium	https://ClinicalTrials.gov/show/NCT02534233	Enrolling by invitation	Johns Hopkins University	2023-08-31
NCT02521285	Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation	https://ClinicalTrials.gov/show/NCT02521285	Active, not recruiting	National Cancer Institute (NCI)	2019-06-18
NCT02514525	Multi-center Clinical Study to Evaluate the C2 CryoBalloon Focal Ablation System	https://ClinicalTrials.gov/show/NCT02514525	Active, not recruiting	C2 Therapeutics, Inc.	2021-05-31
NCT02513784	Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome	https://ClinicalTrials.gov/show/NCT02513784	Completed	Columbia University	2017-12-31
NCT02498041	The Efficacy and Patient Tolerance of Ultrathin Nasal Endoscopy to Detect Barrett’s Oesophagus	https://ClinicalTrials.gov/show/NCT02498041	Completed	University of Cambridge	2012-07-31
NCT02455648	Autologous Cell Sheets Transplantation After ESD in the Esophagus	https://ClinicalTrials.gov/show/NCT02455648	Completed	Karolinska University Hospital	2018-03-25
NCT02451124	Non-endoscopic Brushing of the Esophagus Using a Non-endoscopic Inflatable Balloon of the Esophagus in Screening for Barrett Esophagus	https://ClinicalTrials.gov/show/NCT02451124	Completed	Case Comprehensive Cancer Center	2016-08-11
NCT02445014	Pilot Study to Image the Esophagus Using a SECM Tethered Endoscopic Capsule	https://ClinicalTrials.gov/show/NCT02445014	Completed	Massachusetts General Hospital	2016-01-31
NCT02422433	Capsule Marking Using an OFDI Capsule	https://ClinicalTrials.gov/show/NCT02422433	Active, not recruiting	Massachusetts General Hospital	2021-10-31
NCT02395471	Cytosponge Adequacy Study Evaluation II	https://ClinicalTrials.gov/show/NCT02395471	Completed	Medtronic - MITG	2018-04-24
NCT02249975	Efficacy of CryoBalloon Focal Ablation System on Human Esophageal Barrett’s Epithelium	https://ClinicalTrials.gov/show/NCT02249975	Completed	C2 Therapeutics, Inc.	2016-12-29
NCT02230410	Cryo Balloon for Residual Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT02230410	Enrolling by invitation	Mayo Clinic	2020-08-31
NCT02210039	Using Spectrally Encoded Confocal Microscopy (SECM) to Visualise the Esophagus Using an SECM Probe	https://ClinicalTrials.gov/show/NCT02210039	Completed	Massachusetts General Hospital	2014-12-31
NCT02204150	Study to Image the Esophagus Using the OFDI Capsule	https://ClinicalTrials.gov/show/NCT02204150	Completed	Massachusetts General Hospital	2015-07-31
NCT02100189	Esophageal Cytology With FISH in Detecting Esophageal Cancer	https://ClinicalTrials.gov/show/NCT02100189	Completed	OHSU Knight Cancer Institute	2015-12-31
NCT02066233	Prospective Study to Compare the Efficacy of E.G.Scan to Detect Barrett’s Esophagus Compared With Standard Endoscopy	https://ClinicalTrials.gov/show/NCT02066233	Completed	Mayo Clinic	2015-10-31
NCT01298999	Trial of a Gastrin Receptor Antagonist in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT01298999	Completed	Columbia University	2017-12-31
NCT01293448	Evaluation of Balloon-based Cryoablation of Human Esophageal Epithelium	https://ClinicalTrials.gov/show/NCT01293448	Completed	C2 Therapeutics, Inc.	2012-01-31
NCT01288612	Comparative Effectiveness of Endoscopic Assessment of Gastroesophageal Reflux and Barretts Esophagus	https://ClinicalTrials.gov/show/NCT01288612	Completed	Mayo Clinic	2013-10-31
NCT03364114	Endorotor Resection In Refractory Barrett’s Dysplasia Patients	https://ClinicalTrials.gov/show/NCT03364114	Recruiting	Interscope, Inc.	2021-10-11
NCT02018367	Accuracy, Yield and Clinical Impact of a Low-Cost HRME in the Early Diagnosis of Esophageal Adenocarcinoma	https://ClinicalTrials.gov/show/NCT02018367	Recruiting	Anandasabapathy, Sharmila, M.D.	2020-12-31
NCT01913223	Endoscopic Sub-mucosal Dissection With the Nestis® Jet Injector System With a Bi-functional Catheter: First Prospective Trial	https://ClinicalTrials.gov/show/NCT01913223	Completed	Hospices Civils de Lyon	2013-12-31
NCT01733719	Barrett&Apos;s Intervention for Dysplasia by Endoscopy	https://ClinicalTrials.gov/show/NCT01733719	Completed	University Hospitals, Leicester	2015-11-30
NCT01694511	Endoscopic Detection of Dysplasia in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT01694511	Completed	Göteborg University	2012-11-30
NCT01630798	A In-Vivo Esophageal Protocol for Detection of Neoplasia in the Digestive Tract	https://ClinicalTrials.gov/show/NCT01630798	Completed	University of Michigan	2013-09-30
NCT01566474	Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot Study	https://ClinicalTrials.gov/show/NCT01566474	Completed	Aragon Institute of Health Sciences	2017-06-30
NCT01465113	Vitamin D Supplementation on 15-Prostaglandin Dehydrogenase Expression in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT01465113	Completed	Case Comprehensive Cancer Center	2016-02-29
NCT01447927	Metformin Hydrochloride in Preventing Esophageal Cancer in Patients With Barrett Esophagus	https://ClinicalTrials.gov/show/NCT01447927	Completed	National Cancer Institute (NCI)	2013-05-31
NCT01439633	Optical Frequency Domain Imaging (OFDI) Surveillance and Image Guided Biopsy of the Esophagus	https://ClinicalTrials.gov/show/NCT01439633	Completed	Massachusetts General Hospital	2014-05-31
NCT01439594	Optical Frequency Domain Imaging (OFDI) Assessment in Radiofrequency Ablation	https://ClinicalTrials.gov/show/NCT01439594	Completed	Massachusetts General Hospital	2014-03-31
NCT01401699	Optical Coherence Tomography (OCT) Based Screening of Esophagus and Gastroesophageal Junction	https://ClinicalTrials.gov/show/NCT01401699	Completed	Massachusetts General Hospital	2011-11-16
NCT01391208	Esophageal Protocol for Detection of Neoplasia in the Digestive Tract	https://ClinicalTrials.gov/show/NCT01391208	Completed	University of Michigan	2012-06-30
NCT01384864	Endoscopic Multispectral Imaging for the Early Detection of Barrett’s Neoplasia	https://ClinicalTrials.gov/show/NCT01384864	Completed	Anandasabapathy, Sharmila, M.D.	2015-12-31
NCT01384227	Evaluation of a Miniaturized Microscope Device for the Detection of Barrett’s Neoplasia: A Pilot Study	https://ClinicalTrials.gov/show/NCT01384227	Completed	Anandasabapathy, Sharmila, M.D.	2011-07-31
NCT01360541	Radiofrequency Ablation for Barrett Oesophagus With Low Grade Dysplasia	https://ClinicalTrials.gov/show/NCT01360541	Active, not recruiting	Assistance Publique - Hôpitaux de Paris	2019-05-31
NCT04329000	On-demand PPI Therapy is Effective on Controlling Symptoms in Patients With Barrett’s Esophagus.	https://ClinicalTrials.gov/show/NCT04329000	Completed	Kaohsiung Veterans General Hospital.	2019-02-13
NCT04293458	Efficacy of EsoGuard on Samples Collected Using EsoCheck Versus EGD for the Diagnosis of BE	https://ClinicalTrials.gov/show/NCT04293458	Recruiting	PAVmed Inc.	2022-12-31
NCT04154748	Argon Plasma Coagulation for Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT04154748	Completed	Maria Sklodowska-Curie Institute - Oncology Center	2015-02-10
NCT04054713	Acetic Acid for the Detection of Esophageal Neoplasms	https://ClinicalTrials.gov/show/NCT04054713	Recruiting	Coordinación de Investigación en Salud, Mexico	2019-12-03
NCT03990025	Linked Color Imaging vs White Light Imaging for Detection of Gastric Cancer Precursors	https://ClinicalTrials.gov/show/NCT03990025	Recruiting	Changi General Hospital	2020-10-17
NCT03877601	Detection of Early Esophageal Cancer by NIR-FME.	https://ClinicalTrials.gov/show/NCT03877601	Recruiting	University Medical Center Groningen	2021-03-31
NCT03830801	Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT03830801	Active, not recruiting	Massachusetts General Hospital	2020-12-06
NCT03814824	Volumetric Laser Endomicroscopy With Intelligent Real-time Image Segmentation (IRIS)	https://ClinicalTrials.gov/show/NCT03814824	Recruiting	Northwell Health	2020-06-30
NCT03813381	CAlorie and Protein REstriction PROgram in Barrett’s Esophagus Patients (CARE-PRO).	https://ClinicalTrials.gov/show/NCT03813381	Enrolling by invitation	Istituto Oncologico Veneto IRCCS	2020-12-31
NCT03670134	Predict Recurrence of Barrett’s Esophagus After Complete Eradication of Intestinal Metaplasia	https://ClinicalTrials.gov/show/NCT03670134	Recruiting	Mayo Clinic	2022-10-31
NCT03621319	Eradicating Barrett’s Esophagus Using Radiofrequency Ablation or a Novel Hybrid Argon Plasma Coagulation Technique	https://ClinicalTrials.gov/show/NCT03621319	Recruiting	Erbe Elektromedizin GmbH	2020-07-31
NCT03589443	Study of Multiplexed Heptapeptides for Detection of Neoplasia in the Esophagus	https://ClinicalTrials.gov/show/NCT03589443	Completed	University of Michigan	2019-02-04
NCT03554356	Nitrous Oxide For Endoscopic Ablation of Refractory Barrett’s Esophagus (NO FEAR-BE)	https://ClinicalTrials.gov/show/NCT03554356	Active, not recruiting	University of North Carolina, Chapel Hill	2021-07-31
NCT03471052	Radiofrequency Ablation vs Sham Procedure for Symptomatic Cervical Inlet Patch	https://ClinicalTrials.gov/show/NCT03471052	Recruiting	Guy’s and St Thomas’ NHS Foundation Trust	2021-01-30
NCT03459339	Coordinating Center: Natural History of Barrett’s Esophagus Using Tethered Capsule Endomicroscopy	https://ClinicalTrials.gov/show/NCT03459339	Recruiting	Massachusetts General Hospital	2021-09-30
NCT03434834	OCT Pilot in Esophagus	https://ClinicalTrials.gov/show/NCT03434834	Completed	Duke University	2020-02-25
NCT03427346	Neoplastic Barrett Esophagus: Endoscopic Piecemeal vs. En Bloc Resection	https://ClinicalTrials.gov/show/NCT03427346	Recruiting	Universitätsklinikum Hamburg-Eppendorf	2020-03-31
NCT03418584	Application of hybridAPC in the Treatment of Barrett	https://ClinicalTrials.gov/show/NCT03418584	Recruiting	Changhai Hospital	2020-12-05
NCT03417570	Cap Assisted Upper Endoscopy Versus High Definition White Light Endoscopy and Narrow Band Imaging Alone In The Detection Of Visible Lesions Barrett’s Esophagus: A Randomized Tandem Study	https://ClinicalTrials.gov/show/NCT03417570	Active, not recruiting	Washington University School of Medicine	2021-06-30
NCT01238042	Study To Determine The Maximum Range of Light Doses At Two HPPH Doses With Acceptable Normal Tissue Toxicity For PDT Treatment Of High Grade Dysplasia,CIS or Early Adenocarcinoma In Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT01238042	Completed	Roswell Park Cancer Institute	2004-10-31
NCT01236443	Study of Photodynamic Therapy (PDT) Using HPPH in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT01236443	Completed	Roswell Park Cancer Institute	2003-05-31
NCT01124994	Confocal Laser Endomicroscopy and Endoscopic Mucosal Resection	https://ClinicalTrials.gov/show/NCT01124994	Completed	Medical University of Vienna	2013-07-31
NCT01124214	Confocal Endomicroscopy for Improved Diagnosis of Barrett’s Esophagus and Early Esophageal Cancer(CEBE Study)	https://ClinicalTrials.gov/show/NCT01124214	Completed	Johns Hopkins University	2012-12-31
NCT01097304	Ursodiol in Treating Patients With Barrett Esophagus and Low-Grade Dysplasia	https://ClinicalTrials.gov/show/NCT01097304	Completed	National Cancer Institute (NCI)	2014-04-30
NCT01093755	Does Intensive Acid Suppression Reduce Esophageal Inflammation and Recurrent Barrett’s Esophagus Following Ablation?	https://ClinicalTrials.gov/show/NCT01093755	Completed	Mayo Clinic	2014-11-30
NCT01032044	CLE for Assessment of Neoplasia After Mucosal Ablation or Resection of Gastrointestinal Neoplasia	https://ClinicalTrials.gov/show/NCT01032044	Completed	Mauna Kea Technologies	2011-04-30
NCT00987857	Endoscopy Every 2 Years or Only as Needed in Monitoring Patients With Barrett Esophagus	https://ClinicalTrials.gov/show/NCT00987857	Active, not recruiting	Gloucestershire Hospitals NHS Foundation Trust	2022-05-31
NCT00872755	Nissen and Gastroplasty in Gastroesophageal Reflux Disease (GERD)	https://ClinicalTrials.gov/show/NCT00872755	Completed	G. Hatzikosta General Hospital	2008-04-30
NCT00858858	Clinical Studies on Bile Acids in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00858858	Completed	VA Office of Research and Development	2013-03-31
NCT02284802	Early Detection of Tumors of the Digestive Tract by Confocal Endomicroscopy	https://ClinicalTrials.gov/show/NCT02284802	Recruiting	Instituto do Cancer do Estado de São Paulo	2018-08-31
NCT02606292	Photoacoustic Endoscopy of Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT02606292	Completed	Washington University School of Medicine	2016-08-31
NCT02579460	Reflux-Induced Oxidative Stress in Barrett’s Esophagus: Response, Repair, and Epithelial-Mesenchymal-Transition	https://ClinicalTrials.gov/show/NCT02579460	Enrolling by invitation	Dallas VA Medical Center	2021-10-31
NCT00754468	Study of CryoSpray Ablation(TM)to Determine Treatment Effect, Depth of Injury, and Side Effects in the Esophagus.	https://ClinicalTrials.gov/show/NCT00754468	Completed	CSA Medical, Inc.	2012-03-31
NCT00695227	Screening for Barrett’s Esophagus in Otolaryngology Patients	https://ClinicalTrials.gov/show/NCT00695227	Completed	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)	2011-12-31
NCT00650988	Cryotherapy for Barrett’s Esophagus and Early Esophageal Cancers	https://ClinicalTrials.gov/show/NCT00650988	Completed	Case Comprehensive Cancer Center	2008-05-31
NCT00637988	Barrett’s Esophagus - 315 - 3 Way Cross Over	https://ClinicalTrials.gov/show/NCT00637988	Completed	AstraZeneca	2003-06-30
NCT00637559	Barrett’s Esophagus - 315 - 3 Way Cross-Over	https://ClinicalTrials.gov/show/NCT00637559	Completed	AstraZeneca	2003-04-30
NCT00587600	Biomarkers in Phototherapy of Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00587600	Completed	Mayo Clinic	2017-04-21
NCT00576498	Novel Imaging Techniques in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00576498	Completed	Midwest Biomedical Research Foundation	2009-05-31
NCT00573911	Acid Reflux and Stromal Fibroblasts in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00573911	Completed	Mayo Clinic	2011-01-31
NCT00489268	Micro-Layer Ablation of Barrett’s Metaplasia- A Two-Phase, Multi-Center Trial - Extension of Follow-up to 5 Years	https://ClinicalTrials.gov/show/NCT00489268	Completed	Medtronic - MITG	2007-02-28
NCT00487695	Confocal Endomicroscopy for Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00487695	Completed	Johns Hopkins University	2008-05-31
NCT00474903	Esomeprazole Magnesium With or Without Aspirin in Preventing Esophageal Cancer in Patients With Barrett Esophagus	https://ClinicalTrials.gov/show/NCT00474903	Completed	National Cancer Institute (NCI)	2011-03-31
NCT00449995	Confocal Laserscanning Microscopy for Detection of Barretts Esophagus	https://ClinicalTrials.gov/show/NCT00449995	Completed	Technische Universität München	2008-07-31
NCT00411151	Efficacy and Safety of Sunitinib in Metastatic Gastric Cancer	https://ClinicalTrials.gov/show/NCT00411151	Completed	Johannes Gutenberg University Mainz	2009-07-31
NCT00352261	An Open Label pH Comparison of Esomeprazole and Lansoprazole in Barrett’s Esophagus Patients	https://ClinicalTrials.gov/show/NCT00352261	Completed	AstraZeneca	NA
NCT00282672	Ablation of Intestinal Metaplasia Containing Dysplasia	https://ClinicalTrials.gov/show/NCT00282672	Completed	Medtronic - MITG	2014-04-30
NCT00233935	Defined Green Tea Catechin Extract in Preventing Esophageal Cancer in Patients With Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00233935	Completed	National Cancer Institute (NCI)	2010-11-30
NCT00217087	Endoscopic Therapy of Early Cancer in Barretts Esophagus	https://ClinicalTrials.gov/show/NCT00217087	Completed	Mayo Clinic	2012-06-30
NCT00848237	HALO Patient Registry: Ablation of Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00848237	Completed	Medtronic - MITG	2014-07-31
NCT00003076	Eflornithine to Prevent Cancer in Patients With Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00003076	Completed	University of Michigan Rogel Cancer Center	2002-06-30
NCT00005878	Celecoxib to Prevent Cancer in Patients With Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00005878	Completed	Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins	2005-09-30
NCT00795184	Detection Of Neoplastic Tissue in Barrett’s Esophagus With In vivO Probe-based Confocal Endomicroscopy	https://ClinicalTrials.gov/show/NCT00795184	Completed	Mauna Kea Technologies	2009-09-30

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT04457193	Outcomes After Transoral Incisionless Fundoplication (TIF) Following Successful Endoscopic Ablation for Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT04457193	Enrolling by invitation	Johns Hopkins University	2023-06-07
NCT04301986	Patient Acceptance and Preference Among Screening Modalities for Detection of Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT04301986	Enrolling by invitation	University of North Carolina, Chapel Hill	2021-07-31
NCT03375060	Histology Post-Endoscopic Eradication Therapy (EET)	https://ClinicalTrials.gov/show/NCT03375060	Completed	Northwestern University	2017-11-05
NCT03316053	Cell Marker Predictors in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT03316053	Active, not recruiting	The Guthrie Clinic	2020-12-01
NCT03191604	Impact of NBI on Patients Undergoing Endoscopic Eradication Therapy	https://ClinicalTrials.gov/show/NCT03191604	Completed	Northwestern University	2019-05-10
NCT03167970	Evaluation of Performance Characteristics of Capsule Endoscopy With PillCam UGI Capsule Compared to Standard Endoscopy	https://ClinicalTrials.gov/show/NCT03167970	Completed	Midwest Biomedical Research Foundation	2017-12-06
NCT03060642	The Microenvironment in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT03060642	Enrolling by invitation	Columbia University	2021-01-01
NCT03015389	Wide Area Transepithelial Sample Esophageal Biopsy Combined With Computer Assisted 3-Dimensional Tissue Analysis (WATS3D) For the Detection of High Grade Esophageal Dysplasia and Adenocarcinoma	https://ClinicalTrials.gov/show/NCT03015389	Recruiting	CDx Diagnostics	2019-02-28
NCT03008980	The Analysis of WATS3D (Wide Area Transepithelial Sample Biopsy With 3-Dimensional Computer-Assisted Analysis) Increased Yield of Barrett’s Esophagus and Esophageal Dysplasia	https://ClinicalTrials.gov/show/NCT03008980	Recruiting	CDx Diagnostics	2020-12-31
NCT02634645	TREAT-BE Study (Treatment With Resection and Endoscopic Ablation Techniques for Barrett’s Esophagus)	https://ClinicalTrials.gov/show/NCT02634645	Recruiting	University of Colorado, Denver	2027-01-31
NCT02632682	Confocal Laser Endomicroscopy vs Conventional Histology for the Identification of Intestinal Metaplasia	https://ClinicalTrials.gov/show/NCT02632682	Completed	Minnesota Institute for Minimally Invasive Surgery	2016-08-31
NCT03387982	Balloon Cryotherapy vs. Radiofrequency Ablation Pain Study	https://ClinicalTrials.gov/show/NCT03387982	Active, not recruiting	Geisinger Clinic	2022-10-31
NCT02495051	Esophageal Atresia: Metaplasia, Barrett	https://ClinicalTrials.gov/show/NCT02495051	Completed	University Hospital, Lille	2013-03-31
NCT02427269	UNC Barrett’s Esophagus and Esophageal Cancer Biorepository	https://ClinicalTrials.gov/show/NCT02427269	Active, not recruiting	University of North Carolina, Chapel Hill	2025-05-31
NCT02366039	Probe-based Volumetric Laser Endomicroscopy (pVLE) of Endoscopic Mucosal Resection (EMR) Tissue in Patients With Barrett’s Dysplasia	https://ClinicalTrials.gov/show/NCT02366039	Enrolling by invitation	Mayo Clinic	2020-08-31
NCT02106910	Non-Endoscopic Surveillance for Barrett’s Esophagus Following Ablative Therapy	https://ClinicalTrials.gov/show/NCT02106910	Enrolling by invitation	University of North Carolina, Chapel Hill	2020-05-31
NCT02075905	Stratifying Risk in Barrett’s Esophagus: A Pilot Study for Biomarker-based Patient Management	https://ClinicalTrials.gov/show/NCT02075905	Completed	University of North Carolina, Chapel Hill	2015-08-31
NCT02066701	Gene Methylation in the Diagnosis of Barrett’s Esophagus: Identification of Candidate Diagnostic Markers	https://ClinicalTrials.gov/show/NCT02066701	Completed	Mayo Clinic	2016-12-31
NCT01306799	To Learn How Bone Structure and Bone Mass Change After Long-term PPI Use	https://ClinicalTrials.gov/show/NCT01306799	Completed	University of Pennsylvania	2015-04-30
NCT01286155	Epidemiology of Barrett’s Esophagus: A Population Based Study	https://ClinicalTrials.gov/show/NCT01286155	Completed	Mayo Clinic	2011-06-30
NCT01281618	Influence of Acid Reflux on Stromal Epithelial Interaction in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT01281618	Completed	Mayo Clinic	2011-06-30
NCT01882478	Cryotherapy -BEATS-RF Ablation Trial	https://ClinicalTrials.gov/show/NCT01882478	Active, not recruiting	Mayo Clinic	2020-06-30
NCT01787864	Prevalence of Dysplasia of the Gastric Cardia	https://ClinicalTrials.gov/show/NCT01787864	Completed	University of North Carolina, Chapel Hill	2017-05-31
NCT01633411	Evaluation of Effect of CryoBalloon Focal Ablation System on Human Esophageal Barrett’s Epithelium	https://ClinicalTrials.gov/show/NCT01633411	Completed	C2 Therapeutics, Inc.	2014-05-31
NCT01568723	Betrnet Stem Cells and the Origins of Barrett’s Esophagus Project 3 RF Ablation	https://ClinicalTrials.gov/show/NCT01568723	Active, not recruiting	Mayo Clinic	2020-08-31
NCT01503411	High Resolution Optical Imaging of Barrett’s Esophagus Using Nvision Volumetric Laser Endomicroscopy (VLE)	https://ClinicalTrials.gov/show/NCT01503411	Completed	NinePoint Medical	2014-03-31
NCT01484925	BETERNet Notch Signaling and Novel Biomarkers for Barretts Esophagus	https://ClinicalTrials.gov/show/NCT01484925	Completed	Abramson Cancer Center of the University of Pennsylvania	2018-11-30
NCT01374074	Racial Disparity in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT01374074	Completed	University of North Carolina, Chapel Hill	2014-01-31
NCT01373125	Is the Neosquamous Epithelium “Normal” Following Endoscopic Ablation of Dysplastic Barrett’s Esophagus?	https://ClinicalTrials.gov/show/NCT01373125	Completed	University of North Carolina, Chapel Hill	2014-10-31
NCT04214119	EsophaCap for the Detection of Early Esophageal Carcinoma	https://ClinicalTrials.gov/show/NCT04214119	Recruiting	Johns Hopkins University	2025-12-19
NCT04151524	Classification of Adenocarcinoma of the Esophagogastric Junction	https://ClinicalTrials.gov/show/NCT04151524	Active, not recruiting	St. James’s Hospital, Ireland	2019-12-25
NCT03859557	The Evaluation of Patients With Esophageal and Foregut Disorders With WATS (Wide Area Transepithelial Sample With 3-Dimensional Computer-Assisted Analysis) vs. 4-Quadrant Forceps Biopsy	https://ClinicalTrials.gov/show/NCT03859557	Completed	CDx Diagnostics	2018-12-31
NCT03835663	The Bacterial Composition of the Stomach in Reflux Disease	https://ClinicalTrials.gov/show/NCT03835663	Recruiting	Imperial College London	2019-06-01
NCT03685799	Impact of Histologic Concordance Between Biopsies and the Endoscopic Resection Specimen, in the Treatment of Barrett’s Esophagus in Dysplasia, on the Recurrence of Dysplasia	https://ClinicalTrials.gov/show/NCT03685799	Completed	Institut Paoli-Calmettes	2016-06-30
NCT03526328	DCLK1 as a Marker/Indicator of Stem Cell Response in Barrett’s Esophagus/Esophageal Adenocarcinoma	https://ClinicalTrials.gov/show/NCT03526328	Completed	University of Oklahoma	2019-08-13
NCT01188980	Early Increase in Blood Supply in Patients With Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT01188980	Completed	Mayo Clinic	2013-04-30
NCT01084629	The Role of the Fujinon Intelligent Chromo Endoscopy (FICEâ„¢) in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT01084629	Recruiting	Mayo Clinic	2020-09-30
NCT00955019	Novel Method of Surveillance in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00955019	Completed	Mayo Clinic	2009-08-31
NCT00943280	Barrett’s Esophagus in Olmsted County	https://ClinicalTrials.gov/show/NCT00943280	Completed	Mayo Clinic	2010-01-31
NCT00909350	Micro-RNA (miR) Expression in Upper Gastrointestinal Mucosal Tissue	https://ClinicalTrials.gov/show/NCT00909350	Completed	Mayo Clinic	2008-11-30
NCT00885469	PillCam® ESO 2 in Esophageal Pathologies	https://ClinicalTrials.gov/show/NCT00885469	Completed	Medtronic - MITG	2009-03-31
NCT00844077	Preliminary Longitudinal Validation of Biomarkers Predictive of Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00844077	Completed	University of Michigan	2011-04-30
NCT02198976	Australian Barrett’s Cohort With Dysplasia and Early Cancer Study	https://ClinicalTrials.gov/show/NCT02198976	Recruiting	Western Sydney Local Health District	2020-04-30
NCT00747448	CryoSpray Ablation (TM) GI Patient Registry	https://ClinicalTrials.gov/show/NCT00747448	Completed	CSA Medical, Inc.	2013-06-30
NCT00590239	Barrett’s Esophagus Related Neoplasia (BERN) Project	https://ClinicalTrials.gov/show/NCT00590239	Recruiting	Midwest Biomedical Research Foundation	2021-11-30
NCT00588575	Ramanspectroscopy in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00588575	Completed	Mayo Clinic	2007-05-31
NCT00587652	Methylene Blue Chromoendoscopy in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00587652	Completed	Mayo Clinic	2009-12-31
NCT00587314	The Effect of Ablation Therapy on Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00587314	Enrolling by invitation	Mayo Clinic	2020-01-31
NCT00587184	Confocal Microscopy in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00587184	Completed	Mayo Clinic	2013-02-28
NCT00586989	Endoscopic Tri-Modal Imaging in Patients With Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00586989	Completed	Mayo Clinic	2010-02-28
NCT00586872	Endoscopic Mucosal Resection (EMR) in Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00586872	Enrolling by invitation	Mayo Clinic	2025-10-31
NCT00574327	Progression of Gastroesophageal Reflux Disease and Barrett’s Esophagus and the Creation of a Barrett’s Registry	https://ClinicalTrials.gov/show/NCT00574327	Recruiting	Midwest Biomedical Research Foundation	2023-10-31
NCT00513331	Barrett’s Esophagus & Gastroesophageal Reflux Disease	https://ClinicalTrials.gov/show/NCT00513331	Completed	Valley Health System	2013-12-31
NCT00445653	Risk Factors for Barrett’s Esophagus in Patients With BE, Gastroesophageal Reflux, or Gastrointestinal Bleeding	https://ClinicalTrials.gov/show/NCT00445653	Completed	Massachusetts General Hospital	2013-03-31
NCT00431756	Novel Biomarkers in the Neoplastic Progression of Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00431756	Active, not recruiting	Johns Hopkins University	2022-06-30
NCT00288119	Genetic Determinants of Barrett’s Esophagus and Esophageal Adenocarcinoma	https://ClinicalTrials.gov/show/NCT00288119	Recruiting	University Hospitals Cleveland Medical Center	2022-04-30
NCT00081354	Early Detection of Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT00081354	Completed	National Institutes of Health Clinical Center (CC)	2013-01-01

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT02988934	The WATS3D (Wide Area Transepithelial Sample Biopsy With 3-Dimensional Computer-Assisted Analysis) U.S. Registry	https://ClinicalTrials.gov/show/NCT02988934	Recruiting	CDx Diagnostics	2026-04-30
NCT02793479	Radiofrequency Ablation in Patients With Barrett’s Esophagus	https://ClinicalTrials.gov/show/NCT02793479	Recruiting	Austrian Society Of Surgical Oncology	2020-12-31
NCT02583087	ESD for the Treatment of Early Barrett’s Neoplasia	https://ClinicalTrials.gov/show/NCT02583087	Recruiting	Hôpital Cochin	2019-04-30
NCT02482701	The Captivator EMR Registry	https://ClinicalTrials.gov/show/NCT02482701	Completed	Boston Scientific Corporation	2017-05-31
NCT01802203	trūFreeze® Spray Cryotherapy Patient Registry	https://ClinicalTrials.gov/show/NCT01802203	Active, not recruiting	US Endoscopy Group Inc.	2021-08-31
NCT01776346	Barrett’s Esophagus Patient Registry	https://ClinicalTrials.gov/show/NCT01776346	Recruiting	Massachusetts General Hospital	2021-12-31
NCT04312633	Clinical Utility of WATS3D: A 5-Year Prospective Study	https://ClinicalTrials.gov/show/NCT04312633	Recruiting	CDx Diagnostics	2025-04-01
NCT03853772	The Johns Hopkins Heartburn Center Registry	https://ClinicalTrials.gov/show/NCT03853772	Enrolling by invitation	Johns Hopkins University	2025-12-31