Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 176
interventional 111
Observational 57
Registry 8

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Device 41
Drug 21
Procedure 19
Device|Procedure 5
Drug|placebo 5
Diagnostic Test 4
Other 4
Device|Other 3
Other|Procedure 2
Behavioral 1
Device|Drug 1
Device|Other|Procedure 1
Diagnostic Test|Drug 1
Drug|Other 1
Drug|Other|placebo 1
Drug|Procedure 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 66
NA 6
United Kingdom 5
France 4
Netherlands 4
Germany 3
Sweden 3
United States|Netherlands 2
United States|United Kingdom 2
Australia|Belgium|Germany|Netherlands|Switzerland|United Kingdom 1
Austria 1
Brazil 1
China 1
Czechia 1
Greece 1
Mexico 1
Singapore 1
Spain 1
United States|Canada 1
United States|Canada|Puerto Rico 1
United States|France|Germany 1
United States|France|United Kingdom 1
United States|Germany 1
United States|Puerto Rico 1
United States|Spain 1

Sites per Study

Site_count Study_Count
1 72
2 9
3 5
4 4
5 8
6 1
7 2
8 1
10 3
11 1
12 2
14 1
19 1
28 1

Phase

Phase Study_Count
N/A 73
Phase 2 13
Phase 1 8
Phase 4 7
Early Phase 1 6
Phase 3 2
Phase 1/Phase 2 1
Phase 2/Phase 3 1

Number of Arms

Number_of_Arms Count_of_Studies
1 54
2 40
3 6
4 4
5 1
NA 6

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 8.0 1.0000 16 50 20.00000 208 46.0 7.00000
1st Qu. 27.0 30.0000 18 50 33.00000 208 54.5 31.00000
Median 31.5 76.0000 23 50 66.50000 208 63.0 50.00000
Mean 29.0 241.9863 30 50 73.33333 208 63.0 52.71429
3rd Qu. 36.0 150.0000 34 50 105.50000 208 71.5 80.00000
Max. 40.0 5521.0000 60 50 152.00000 208 80.0 90.00000

Trial Group Type

group_type Group_Count
Experimental 88
Active Comparator 51
Other 17
No Intervention 8
NA 6
Placebo Comparator 5
Sham Comparator 4

Intervention Model

intervention_model Study_Count
Single Group Assignment 61
Parallel Assignment 35
Crossover Assignment 12
NA 2
Sequential Assignment 1

Primary Purpose

primary_purpose Study_Count
Treatment 41
Diagnostic 30
Prevention 12
Screening 11
Basic Science 7
Device Feasibility 4
Other 4
Health Services Research 1
NA 1

Observational Studies

Studies by Country

Country Study_Count
United States 46
United States|Netherlands 2
Australia 1
Belgium 1
Belgium|Canada|France|Luxembourg 1
France 1
Ireland 1
NA 1
United Kingdom 1
United States|Canada 1
United States|Netherlands|United Kingdom 1

Sites per Study

Site_count Study_Count
1 41
2 5
3 2
4 3
6 2
8 1
10 2
20 1

Enrollment Metrics

Measure Observational
Min 10.000
1st Qu 60.000
Median 125.000
Mean 1745.825
3rd Qu 300.000
Max 75000.000

Observation Model

observational_model Study_Count
Cohort 36
Case-Only 8
Case-Control 7
Case Control 2
Other 2
NA 2

Time Perspective

time_perspective Study_Count
Prospective 40
Cross-Sectional 8
Retrospective 5
Other 2
NA 2

Registries

Studies by Country

Country Study_Count
United States 5
Austria 1
France 1
United States|Belgium|Canada|Germany|Netherlands|United Kingdom 1

Sites per Study

Site_count Study_Count
1 6
13 1
16 1

Enrollment Metrics

Measure Registries
Min 150.00
1st Qu 287.00
Median 625.00
Mean 12870.75
3rd Qu 3250.00
Max 90000.00

Registry Model

observational_model Study_Count
Cohort 5
Case-Only 2
Case Control 1

Time Perspective

time_perspective Study_Count
Prospective 8

Follow-up

target_duration Study_Count
5 Years 5
10 Years 1
3 Years 1
30 Days 1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id brief_title link overall_status source primary_completion_date
NCT04316975 Utility Of Mutational Load As A Predictor For Endoscopic Treatment Response In Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT04316975 Recruiting University of North Carolina, Chapel Hill 2021-03-31
NCT03366012 Rapid Assessment of Esophageal Adenocarcinoma Risk Test https://ClinicalTrials.gov/show/NCT03366012 Enrolling by invitation Columbia University 2021-08-31
NCT03278327 Impact of an Endoscopic Treatment of the Line Z on the Gastronomic Recurrence and the Gastro- Esophageal Reflux Disease in the Care of the Adenocarcinoma of Barrett’s Oesophagus https://ClinicalTrials.gov/show/NCT03278327 Recruiting Institut Paoli-Calmettes 2019-06-30
NCT03240679 Endoscopic Mucosal Resection and Cellular Matrix https://ClinicalTrials.gov/show/NCT03240679 Enrolling by invitation Mayo Clinic 2022-04-01
NCT03222635 Prospective Endoscopic Follow-up of Patients With Submucosal Esophageal Adenocarcinoma (The PREFER Trial) https://ClinicalTrials.gov/show/NCT03222635 Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) 2025-07-25
NCT03193216 The Impact of Adjuvant Liquid Alginate on Endoscopic Ablation Therapy of Complicated Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT03193216 Active, not recruiting Medical University of South Carolina 2022-06-30
NCT03120195 EndoRotor® Ablation of Barrett’s Esophagus: Safety and Feasibility Study https://ClinicalTrials.gov/show/NCT03120195 Completed Foundation for Liver Research 2019-01-21
NCT03097666 Evaluation of Safety and Dose Response Using C2 CryoBalloonâ„¢ Swipe Ablation System for Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT03097666 Active, not recruiting C2 Therapeutics, Inc. 2018-11-01
NCT03077594 Characterization of the Neo-squamous Epithelial Barrier https://ClinicalTrials.gov/show/NCT03077594 Recruiting Mayo Clinic 2020-09-30
NCT03073226 A Prospective Study Comparing the Accuracy of Olympus Lucera Spectrum Technology vs Olympus Lucera Elite Technology in the in Vivo Diagnosis of Barrett’s Oesophagus and Colorectal Polyps: The ELITE Study https://ClinicalTrials.gov/show/NCT03073226 Completed Portsmouth Hospitals NHS Trust 2017-11-30
NCT02994693 Natural History of Barrett’s Esophagus Using Tethered Capsule Endomicroscopy https://ClinicalTrials.gov/show/NCT02994693 Recruiting Massachusetts General Hospital 2023-12-31
NCT02947971 Pilot Study for TCE Imaging of the Esophagus Using an OFDI Capsule With a Compact Imaging System https://ClinicalTrials.gov/show/NCT02947971 Recruiting Massachusetts General Hospital 2020-09-30
NCT02922049 pCLE in the Detection of Esophageal and Gastric Lesions and Intestinal Metaplasia or Dysplasia in Patients After Endoscopic Treatment of BORN https://ClinicalTrials.gov/show/NCT02922049 Completed Institute for Clinical and Experimental Medicine 2019-04-30
NCT02890979 Swallowable Sponge Cell Sampling Device and Next Generation Sequencing in Detecting Esophageal Cancer in Patients With Low or High Grade Dysplasia, Barrett Esophagus, or Gastroesophageal Reflux Disease https://ClinicalTrials.gov/show/NCT02890979 Active, not recruiting OHSU Knight Cancer Institute 2020-12-31
NCT02879721 Expression and Function of the Renin-Angiotensin System in the Esophagus https://ClinicalTrials.gov/show/NCT02879721 Completed Göteborg University 2012-12-31
NCT02864043 Barrett’s Dysplasia Detection Pilot Trial Using the NvisionVLE® Imaging System https://ClinicalTrials.gov/show/NCT02864043 Active, not recruiting NinePoint Medical 2020-06-01
NCT02852525 Confocal Laser Probe to Treat Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT02852525 Completed Ochsner Health System 2015-12-31
NCT02729948 Tethered Capsule Endoscope in Screening Patients With Barrett Esophagus https://ClinicalTrials.gov/show/NCT02729948 Completed University of Washington 2017-08-03
NCT02688114 Healing of the Esophageal Mucosa After RFA of Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT02688114 Enrolling by invitation Dallas VA Medical Center 2020-05-31
NCT01733147 Modulation of Esophageal Inflammation in Barrett’s Esophagus by Omega-3 Fatty Acids https://ClinicalTrials.gov/show/NCT01733147 Active, not recruiting Mayo Clinic 2021-01-31
NCT02560623 Minimally-Invasive Detection of Barrett’s Esophagus and Barrett’s Esophagus Related Dysplasia/Carcinoma https://ClinicalTrials.gov/show/NCT02560623 Recruiting Mayo Clinic 2020-12-31
NCT03388047 Feasibility of Multi-Spectral Endoscopic Imaging for Detection of Early Neoplasia in Barrett’s Oesophagus https://ClinicalTrials.gov/show/NCT03388047 Recruiting University of Cambridge 2020-12-31
NCT02549053 Prevalence of Human Papillomavirus in Barrett Esophagus Compared With Controls https://ClinicalTrials.gov/show/NCT02549053 Completed University Hospital, Angers 2015-02-28
NCT02534233 Evaluation of Effect of CryoBalloon Focal Ablation System on Human Esophageal Epithelium https://ClinicalTrials.gov/show/NCT02534233 Enrolling by invitation Johns Hopkins University 2023-08-31
NCT02521285 Aspirin in Preventing Disease Recurrence in Patients With Barrett Esophagus After Successful Elimination by Radiofrequency Ablation https://ClinicalTrials.gov/show/NCT02521285 Active, not recruiting National Cancer Institute (NCI) 2019-06-18
NCT02514525 Multi-center Clinical Study to Evaluate the C2 CryoBalloon Focal Ablation System https://ClinicalTrials.gov/show/NCT02514525 Active, not recruiting C2 Therapeutics, Inc. 2021-05-31
NCT02513784 Trial to Assess the Effects of an Antimicrobial Mouthwash on the Esophageal Microbiome https://ClinicalTrials.gov/show/NCT02513784 Completed Columbia University 2017-12-31
NCT02498041 The Efficacy and Patient Tolerance of Ultrathin Nasal Endoscopy to Detect Barrett’s Oesophagus https://ClinicalTrials.gov/show/NCT02498041 Completed University of Cambridge 2012-07-31
NCT02455648 Autologous Cell Sheets Transplantation After ESD in the Esophagus https://ClinicalTrials.gov/show/NCT02455648 Completed Karolinska University Hospital 2018-03-25
NCT02451124 Non-endoscopic Brushing of the Esophagus Using a Non-endoscopic Inflatable Balloon of the Esophagus in Screening for Barrett Esophagus https://ClinicalTrials.gov/show/NCT02451124 Completed Case Comprehensive Cancer Center 2016-08-11
NCT02445014 Pilot Study to Image the Esophagus Using a SECM Tethered Endoscopic Capsule https://ClinicalTrials.gov/show/NCT02445014 Completed Massachusetts General Hospital 2016-01-31
NCT02422433 Capsule Marking Using an OFDI Capsule https://ClinicalTrials.gov/show/NCT02422433 Active, not recruiting Massachusetts General Hospital 2021-10-31
NCT02395471 Cytosponge Adequacy Study Evaluation II https://ClinicalTrials.gov/show/NCT02395471 Completed Medtronic - MITG 2018-04-24
NCT02249975 Efficacy of CryoBalloon Focal Ablation System on Human Esophageal Barrett’s Epithelium https://ClinicalTrials.gov/show/NCT02249975 Completed C2 Therapeutics, Inc. 2016-12-29
NCT02230410 Cryo Balloon for Residual Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT02230410 Enrolling by invitation Mayo Clinic 2020-08-31
NCT02210039 Using Spectrally Encoded Confocal Microscopy (SECM) to Visualise the Esophagus Using an SECM Probe https://ClinicalTrials.gov/show/NCT02210039 Completed Massachusetts General Hospital 2014-12-31
NCT02204150 Study to Image the Esophagus Using the OFDI Capsule https://ClinicalTrials.gov/show/NCT02204150 Completed Massachusetts General Hospital 2015-07-31
NCT02100189 Esophageal Cytology With FISH in Detecting Esophageal Cancer https://ClinicalTrials.gov/show/NCT02100189 Completed OHSU Knight Cancer Institute 2015-12-31
NCT02066233 Prospective Study to Compare the Efficacy of E.G.Scan to Detect Barrett’s Esophagus Compared With Standard Endoscopy https://ClinicalTrials.gov/show/NCT02066233 Completed Mayo Clinic 2015-10-31
NCT01298999 Trial of a Gastrin Receptor Antagonist in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT01298999 Completed Columbia University 2017-12-31
NCT01293448 Evaluation of Balloon-based Cryoablation of Human Esophageal Epithelium https://ClinicalTrials.gov/show/NCT01293448 Completed C2 Therapeutics, Inc. 2012-01-31
NCT01288612 Comparative Effectiveness of Endoscopic Assessment of Gastroesophageal Reflux and Barretts Esophagus https://ClinicalTrials.gov/show/NCT01288612 Completed Mayo Clinic 2013-10-31
NCT03364114 Endorotor Resection In Refractory Barrett’s Dysplasia Patients https://ClinicalTrials.gov/show/NCT03364114 Recruiting Interscope, Inc. 2021-10-11
NCT02018367 Accuracy, Yield and Clinical Impact of a Low-Cost HRME in the Early Diagnosis of Esophageal Adenocarcinoma https://ClinicalTrials.gov/show/NCT02018367 Recruiting Anandasabapathy, Sharmila, M.D. 2020-12-31
NCT01913223 Endoscopic Sub-mucosal Dissection With the Nestis® Jet Injector System With a Bi-functional Catheter: First Prospective Trial https://ClinicalTrials.gov/show/NCT01913223 Completed Hospices Civils de Lyon 2013-12-31
NCT01733719 Barrett&Apos;s Intervention for Dysplasia by Endoscopy https://ClinicalTrials.gov/show/NCT01733719 Completed University Hospitals, Leicester 2015-11-30
NCT01694511 Endoscopic Detection of Dysplasia in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT01694511 Completed Göteborg University 2012-11-30
NCT01630798 A In-Vivo Esophageal Protocol for Detection of Neoplasia in the Digestive Tract https://ClinicalTrials.gov/show/NCT01630798 Completed University of Michigan 2013-09-30
NCT01566474 Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot Study https://ClinicalTrials.gov/show/NCT01566474 Completed Aragon Institute of Health Sciences 2017-06-30
NCT01465113 Vitamin D Supplementation on 15-Prostaglandin Dehydrogenase Expression in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT01465113 Completed Case Comprehensive Cancer Center 2016-02-29
NCT01447927 Metformin Hydrochloride in Preventing Esophageal Cancer in Patients With Barrett Esophagus https://ClinicalTrials.gov/show/NCT01447927 Completed National Cancer Institute (NCI) 2013-05-31
NCT01439633 Optical Frequency Domain Imaging (OFDI) Surveillance and Image Guided Biopsy of the Esophagus https://ClinicalTrials.gov/show/NCT01439633 Completed Massachusetts General Hospital 2014-05-31
NCT01439594 Optical Frequency Domain Imaging (OFDI) Assessment in Radiofrequency Ablation https://ClinicalTrials.gov/show/NCT01439594 Completed Massachusetts General Hospital 2014-03-31
NCT01401699 Optical Coherence Tomography (OCT) Based Screening of Esophagus and Gastroesophageal Junction https://ClinicalTrials.gov/show/NCT01401699 Completed Massachusetts General Hospital 2011-11-16
NCT01391208 Esophageal Protocol for Detection of Neoplasia in the Digestive Tract https://ClinicalTrials.gov/show/NCT01391208 Completed University of Michigan 2012-06-30
NCT01384864 Endoscopic Multispectral Imaging for the Early Detection of Barrett’s Neoplasia https://ClinicalTrials.gov/show/NCT01384864 Completed Anandasabapathy, Sharmila, M.D. 2015-12-31
NCT01384227 Evaluation of a Miniaturized Microscope Device for the Detection of Barrett’s Neoplasia: A Pilot Study https://ClinicalTrials.gov/show/NCT01384227 Completed Anandasabapathy, Sharmila, M.D. 2011-07-31
NCT01360541 Radiofrequency Ablation for Barrett Oesophagus With Low Grade Dysplasia https://ClinicalTrials.gov/show/NCT01360541 Active, not recruiting Assistance Publique - Hôpitaux de Paris 2019-05-31
NCT04329000 On-demand PPI Therapy is Effective on Controlling Symptoms in Patients With Barrett’s Esophagus. https://ClinicalTrials.gov/show/NCT04329000 Completed Kaohsiung Veterans General Hospital. 2019-02-13
NCT04293458 Efficacy of EsoGuard on Samples Collected Using EsoCheck Versus EGD for the Diagnosis of BE https://ClinicalTrials.gov/show/NCT04293458 Recruiting PAVmed Inc. 2022-12-31
NCT04154748 Argon Plasma Coagulation for Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT04154748 Completed Maria Sklodowska-Curie Institute - Oncology Center 2015-02-10
NCT04054713 Acetic Acid for the Detection of Esophageal Neoplasms https://ClinicalTrials.gov/show/NCT04054713 Recruiting Coordinación de Investigación en Salud, Mexico 2019-12-03
NCT03990025 Linked Color Imaging vs White Light Imaging for Detection of Gastric Cancer Precursors https://ClinicalTrials.gov/show/NCT03990025 Recruiting Changi General Hospital 2020-10-17
NCT03877601 Detection of Early Esophageal Cancer by NIR-FME. https://ClinicalTrials.gov/show/NCT03877601 Recruiting University Medical Center Groningen 2021-03-31
NCT03830801 Pilot Study for OCT Guided In Vivo Laser Capture Microdissection for Assessing the Prognosis of Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT03830801 Active, not recruiting Massachusetts General Hospital 2020-12-06
NCT03814824 Volumetric Laser Endomicroscopy With Intelligent Real-time Image Segmentation (IRIS) https://ClinicalTrials.gov/show/NCT03814824 Recruiting Northwell Health 2020-06-30
NCT03813381 CAlorie and Protein REstriction PROgram in Barrett’s Esophagus Patients (CARE-PRO). https://ClinicalTrials.gov/show/NCT03813381 Enrolling by invitation Istituto Oncologico Veneto IRCCS 2020-12-31
NCT03670134 Predict Recurrence of Barrett’s Esophagus After Complete Eradication of Intestinal Metaplasia https://ClinicalTrials.gov/show/NCT03670134 Recruiting Mayo Clinic 2022-10-31
NCT03621319 Eradicating Barrett’s Esophagus Using Radiofrequency Ablation or a Novel Hybrid Argon Plasma Coagulation Technique https://ClinicalTrials.gov/show/NCT03621319 Recruiting Erbe Elektromedizin GmbH 2020-07-31
NCT03589443 Study of Multiplexed Heptapeptides for Detection of Neoplasia in the Esophagus https://ClinicalTrials.gov/show/NCT03589443 Completed University of Michigan 2019-02-04
NCT03554356 Nitrous Oxide For Endoscopic Ablation of Refractory Barrett’s Esophagus (NO FEAR-BE) https://ClinicalTrials.gov/show/NCT03554356 Active, not recruiting University of North Carolina, Chapel Hill 2021-07-31
NCT03471052 Radiofrequency Ablation vs Sham Procedure for Symptomatic Cervical Inlet Patch https://ClinicalTrials.gov/show/NCT03471052 Recruiting Guy’s and St Thomas’ NHS Foundation Trust 2021-01-30
NCT03459339 Coordinating Center: Natural History of Barrett’s Esophagus Using Tethered Capsule Endomicroscopy https://ClinicalTrials.gov/show/NCT03459339 Recruiting Massachusetts General Hospital 2021-09-30
NCT03434834 OCT Pilot in Esophagus https://ClinicalTrials.gov/show/NCT03434834 Completed Duke University 2020-02-25
NCT03427346 Neoplastic Barrett Esophagus: Endoscopic Piecemeal vs. En Bloc Resection https://ClinicalTrials.gov/show/NCT03427346 Recruiting Universitätsklinikum Hamburg-Eppendorf 2020-03-31
NCT03418584 Application of hybridAPC in the Treatment of Barrett https://ClinicalTrials.gov/show/NCT03418584 Recruiting Changhai Hospital 2020-12-05
NCT03417570 Cap Assisted Upper Endoscopy Versus High Definition White Light Endoscopy and Narrow Band Imaging Alone In The Detection Of Visible Lesions Barrett’s Esophagus: A Randomized Tandem Study https://ClinicalTrials.gov/show/NCT03417570 Active, not recruiting Washington University School of Medicine 2021-06-30
NCT01238042 Study To Determine The Maximum Range of Light Doses At Two HPPH Doses With Acceptable Normal Tissue Toxicity For PDT Treatment Of High Grade Dysplasia,CIS or Early Adenocarcinoma In Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT01238042 Completed Roswell Park Cancer Institute 2004-10-31
NCT01236443 Study of Photodynamic Therapy (PDT) Using HPPH in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT01236443 Completed Roswell Park Cancer Institute 2003-05-31
NCT01124994 Confocal Laser Endomicroscopy and Endoscopic Mucosal Resection https://ClinicalTrials.gov/show/NCT01124994 Completed Medical University of Vienna 2013-07-31
NCT01124214 Confocal Endomicroscopy for Improved Diagnosis of Barrett’s Esophagus and Early Esophageal Cancer(CEBE Study) https://ClinicalTrials.gov/show/NCT01124214 Completed Johns Hopkins University 2012-12-31
NCT01097304 Ursodiol in Treating Patients With Barrett Esophagus and Low-Grade Dysplasia https://ClinicalTrials.gov/show/NCT01097304 Completed National Cancer Institute (NCI) 2014-04-30
NCT01093755 Does Intensive Acid Suppression Reduce Esophageal Inflammation and Recurrent Barrett’s Esophagus Following Ablation? https://ClinicalTrials.gov/show/NCT01093755 Completed Mayo Clinic 2014-11-30
NCT01032044 CLE for Assessment of Neoplasia After Mucosal Ablation or Resection of Gastrointestinal Neoplasia https://ClinicalTrials.gov/show/NCT01032044 Completed Mauna Kea Technologies 2011-04-30
NCT00987857 Endoscopy Every 2 Years or Only as Needed in Monitoring Patients With Barrett Esophagus https://ClinicalTrials.gov/show/NCT00987857 Active, not recruiting Gloucestershire Hospitals NHS Foundation Trust 2022-05-31
NCT00872755 Nissen and Gastroplasty in Gastroesophageal Reflux Disease (GERD) https://ClinicalTrials.gov/show/NCT00872755 Completed G. Hatzikosta General Hospital 2008-04-30
NCT00858858 Clinical Studies on Bile Acids in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00858858 Completed VA Office of Research and Development 2013-03-31
NCT02284802 Early Detection of Tumors of the Digestive Tract by Confocal Endomicroscopy https://ClinicalTrials.gov/show/NCT02284802 Recruiting Instituto do Cancer do Estado de São Paulo 2018-08-31
NCT02606292 Photoacoustic Endoscopy of Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT02606292 Completed Washington University School of Medicine 2016-08-31
NCT02579460 Reflux-Induced Oxidative Stress in Barrett’s Esophagus: Response, Repair, and Epithelial-Mesenchymal-Transition https://ClinicalTrials.gov/show/NCT02579460 Enrolling by invitation Dallas VA Medical Center 2021-10-31
NCT00754468 Study of CryoSpray Ablation(TM)to Determine Treatment Effect, Depth of Injury, and Side Effects in the Esophagus. https://ClinicalTrials.gov/show/NCT00754468 Completed CSA Medical, Inc. 2012-03-31
NCT00695227 Screening for Barrett’s Esophagus in Otolaryngology Patients https://ClinicalTrials.gov/show/NCT00695227 Completed National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 2011-12-31
NCT00650988 Cryotherapy for Barrett’s Esophagus and Early Esophageal Cancers https://ClinicalTrials.gov/show/NCT00650988 Completed Case Comprehensive Cancer Center 2008-05-31
NCT00637988 Barrett’s Esophagus - 315 - 3 Way Cross Over https://ClinicalTrials.gov/show/NCT00637988 Completed AstraZeneca 2003-06-30
NCT00637559 Barrett’s Esophagus - 315 - 3 Way Cross-Over https://ClinicalTrials.gov/show/NCT00637559 Completed AstraZeneca 2003-04-30
NCT00587600 Biomarkers in Phototherapy of Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00587600 Completed Mayo Clinic 2017-04-21
NCT00576498 Novel Imaging Techniques in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00576498 Completed Midwest Biomedical Research Foundation 2009-05-31
NCT00573911 Acid Reflux and Stromal Fibroblasts in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00573911 Completed Mayo Clinic 2011-01-31
NCT00489268 Micro-Layer Ablation of Barrett’s Metaplasia- A Two-Phase, Multi-Center Trial - Extension of Follow-up to 5 Years https://ClinicalTrials.gov/show/NCT00489268 Completed Medtronic - MITG 2007-02-28
NCT00487695 Confocal Endomicroscopy for Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00487695 Completed Johns Hopkins University 2008-05-31
NCT00474903 Esomeprazole Magnesium With or Without Aspirin in Preventing Esophageal Cancer in Patients With Barrett Esophagus https://ClinicalTrials.gov/show/NCT00474903 Completed National Cancer Institute (NCI) 2011-03-31
NCT00449995 Confocal Laserscanning Microscopy for Detection of Barretts Esophagus https://ClinicalTrials.gov/show/NCT00449995 Completed Technische Universität München 2008-07-31
NCT00411151 Efficacy and Safety of Sunitinib in Metastatic Gastric Cancer https://ClinicalTrials.gov/show/NCT00411151 Completed Johannes Gutenberg University Mainz 2009-07-31
NCT00352261 An Open Label pH Comparison of Esomeprazole and Lansoprazole in Barrett’s Esophagus Patients https://ClinicalTrials.gov/show/NCT00352261 Completed AstraZeneca NA
NCT00282672 Ablation of Intestinal Metaplasia Containing Dysplasia https://ClinicalTrials.gov/show/NCT00282672 Completed Medtronic - MITG 2014-04-30
NCT00233935 Defined Green Tea Catechin Extract in Preventing Esophageal Cancer in Patients With Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00233935 Completed National Cancer Institute (NCI) 2010-11-30
NCT00217087 Endoscopic Therapy of Early Cancer in Barretts Esophagus https://ClinicalTrials.gov/show/NCT00217087 Completed Mayo Clinic 2012-06-30
NCT00848237 HALO Patient Registry: Ablation of Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00848237 Completed Medtronic - MITG 2014-07-31
NCT00003076 Eflornithine to Prevent Cancer in Patients With Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00003076 Completed University of Michigan Rogel Cancer Center 2002-06-30
NCT00005878 Celecoxib to Prevent Cancer in Patients With Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00005878 Completed Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 2005-09-30
NCT00795184 Detection Of Neoplastic Tissue in Barrett’s Esophagus With In vivO Probe-based Confocal Endomicroscopy https://ClinicalTrials.gov/show/NCT00795184 Completed Mauna Kea Technologies 2009-09-30

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT04457193 Outcomes After Transoral Incisionless Fundoplication (TIF) Following Successful Endoscopic Ablation for Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT04457193 Enrolling by invitation Johns Hopkins University 2023-06-07
NCT04301986 Patient Acceptance and Preference Among Screening Modalities for Detection of Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT04301986 Enrolling by invitation University of North Carolina, Chapel Hill 2021-07-31
NCT03375060 Histology Post-Endoscopic Eradication Therapy (EET) https://ClinicalTrials.gov/show/NCT03375060 Completed Northwestern University 2017-11-05
NCT03316053 Cell Marker Predictors in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT03316053 Active, not recruiting The Guthrie Clinic 2020-12-01
NCT03191604 Impact of NBI on Patients Undergoing Endoscopic Eradication Therapy https://ClinicalTrials.gov/show/NCT03191604 Completed Northwestern University 2019-05-10
NCT03167970 Evaluation of Performance Characteristics of Capsule Endoscopy With PillCam UGI Capsule Compared to Standard Endoscopy https://ClinicalTrials.gov/show/NCT03167970 Completed Midwest Biomedical Research Foundation 2017-12-06
NCT03060642 The Microenvironment in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT03060642 Enrolling by invitation Columbia University 2021-01-01
NCT03015389 Wide Area Transepithelial Sample Esophageal Biopsy Combined With Computer Assisted 3-Dimensional Tissue Analysis (WATS3D) For the Detection of High Grade Esophageal Dysplasia and Adenocarcinoma https://ClinicalTrials.gov/show/NCT03015389 Recruiting CDx Diagnostics 2019-02-28
NCT03008980 The Analysis of WATS3D (Wide Area Transepithelial Sample Biopsy With 3-Dimensional Computer-Assisted Analysis) Increased Yield of Barrett’s Esophagus and Esophageal Dysplasia https://ClinicalTrials.gov/show/NCT03008980 Recruiting CDx Diagnostics 2020-12-31
NCT02634645 TREAT-BE Study (Treatment With Resection and Endoscopic Ablation Techniques for Barrett’s Esophagus) https://ClinicalTrials.gov/show/NCT02634645 Recruiting University of Colorado, Denver 2027-01-31
NCT02632682 Confocal Laser Endomicroscopy vs Conventional Histology for the Identification of Intestinal Metaplasia https://ClinicalTrials.gov/show/NCT02632682 Completed Minnesota Institute for Minimally Invasive Surgery 2016-08-31
NCT03387982 Balloon Cryotherapy vs. Radiofrequency Ablation Pain Study https://ClinicalTrials.gov/show/NCT03387982 Active, not recruiting Geisinger Clinic 2022-10-31
NCT02495051 Esophageal Atresia: Metaplasia, Barrett https://ClinicalTrials.gov/show/NCT02495051 Completed University Hospital, Lille 2013-03-31
NCT02427269 UNC Barrett’s Esophagus and Esophageal Cancer Biorepository https://ClinicalTrials.gov/show/NCT02427269 Active, not recruiting University of North Carolina, Chapel Hill 2025-05-31
NCT02366039 Probe-based Volumetric Laser Endomicroscopy (pVLE) of Endoscopic Mucosal Resection (EMR) Tissue in Patients With Barrett’s Dysplasia https://ClinicalTrials.gov/show/NCT02366039 Enrolling by invitation Mayo Clinic 2020-08-31
NCT02106910 Non-Endoscopic Surveillance for Barrett’s Esophagus Following Ablative Therapy https://ClinicalTrials.gov/show/NCT02106910 Enrolling by invitation University of North Carolina, Chapel Hill 2020-05-31
NCT02075905 Stratifying Risk in Barrett’s Esophagus: A Pilot Study for Biomarker-based Patient Management https://ClinicalTrials.gov/show/NCT02075905 Completed University of North Carolina, Chapel Hill 2015-08-31
NCT02066701 Gene Methylation in the Diagnosis of Barrett’s Esophagus: Identification of Candidate Diagnostic Markers https://ClinicalTrials.gov/show/NCT02066701 Completed Mayo Clinic 2016-12-31
NCT01306799 To Learn How Bone Structure and Bone Mass Change After Long-term PPI Use https://ClinicalTrials.gov/show/NCT01306799 Completed University of Pennsylvania 2015-04-30
NCT01286155 Epidemiology of Barrett’s Esophagus: A Population Based Study https://ClinicalTrials.gov/show/NCT01286155 Completed Mayo Clinic 2011-06-30
NCT01281618 Influence of Acid Reflux on Stromal Epithelial Interaction in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT01281618 Completed Mayo Clinic 2011-06-30
NCT01882478 Cryotherapy -BEATS-RF Ablation Trial https://ClinicalTrials.gov/show/NCT01882478 Active, not recruiting Mayo Clinic 2020-06-30
NCT01787864 Prevalence of Dysplasia of the Gastric Cardia https://ClinicalTrials.gov/show/NCT01787864 Completed University of North Carolina, Chapel Hill 2017-05-31
NCT01633411 Evaluation of Effect of CryoBalloon Focal Ablation System on Human Esophageal Barrett’s Epithelium https://ClinicalTrials.gov/show/NCT01633411 Completed C2 Therapeutics, Inc. 2014-05-31
NCT01568723 Betrnet Stem Cells and the Origins of Barrett’s Esophagus Project 3 RF Ablation https://ClinicalTrials.gov/show/NCT01568723 Active, not recruiting Mayo Clinic 2020-08-31
NCT01503411 High Resolution Optical Imaging of Barrett’s Esophagus Using Nvision Volumetric Laser Endomicroscopy (VLE) https://ClinicalTrials.gov/show/NCT01503411 Completed NinePoint Medical 2014-03-31
NCT01484925 BETERNet Notch Signaling and Novel Biomarkers for Barretts Esophagus https://ClinicalTrials.gov/show/NCT01484925 Completed Abramson Cancer Center of the University of Pennsylvania 2018-11-30
NCT01374074 Racial Disparity in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT01374074 Completed University of North Carolina, Chapel Hill 2014-01-31
NCT01373125 Is the Neosquamous Epithelium “Normal” Following Endoscopic Ablation of Dysplastic Barrett’s Esophagus? https://ClinicalTrials.gov/show/NCT01373125 Completed University of North Carolina, Chapel Hill 2014-10-31
NCT04214119 EsophaCap for the Detection of Early Esophageal Carcinoma https://ClinicalTrials.gov/show/NCT04214119 Recruiting Johns Hopkins University 2025-12-19
NCT04151524 Classification of Adenocarcinoma of the Esophagogastric Junction https://ClinicalTrials.gov/show/NCT04151524 Active, not recruiting St. James’s Hospital, Ireland 2019-12-25
NCT03859557 The Evaluation of Patients With Esophageal and Foregut Disorders With WATS (Wide Area Transepithelial Sample With 3-Dimensional Computer-Assisted Analysis) vs. 4-Quadrant Forceps Biopsy https://ClinicalTrials.gov/show/NCT03859557 Completed CDx Diagnostics 2018-12-31
NCT03835663 The Bacterial Composition of the Stomach in Reflux Disease https://ClinicalTrials.gov/show/NCT03835663 Recruiting Imperial College London 2019-06-01
NCT03685799 Impact of Histologic Concordance Between Biopsies and the Endoscopic Resection Specimen, in the Treatment of Barrett’s Esophagus in Dysplasia, on the Recurrence of Dysplasia https://ClinicalTrials.gov/show/NCT03685799 Completed Institut Paoli-Calmettes 2016-06-30
NCT03526328 DCLK1 as a Marker/Indicator of Stem Cell Response in Barrett’s Esophagus/Esophageal Adenocarcinoma https://ClinicalTrials.gov/show/NCT03526328 Completed University of Oklahoma 2019-08-13
NCT01188980 Early Increase in Blood Supply in Patients With Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT01188980 Completed Mayo Clinic 2013-04-30
NCT01084629 The Role of the Fujinon Intelligent Chromo Endoscopy (FICEâ„¢) in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT01084629 Recruiting Mayo Clinic 2020-09-30
NCT00955019 Novel Method of Surveillance in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00955019 Completed Mayo Clinic 2009-08-31
NCT00943280 Barrett’s Esophagus in Olmsted County https://ClinicalTrials.gov/show/NCT00943280 Completed Mayo Clinic 2010-01-31
NCT00909350 Micro-RNA (miR) Expression in Upper Gastrointestinal Mucosal Tissue https://ClinicalTrials.gov/show/NCT00909350 Completed Mayo Clinic 2008-11-30
NCT00885469 PillCam® ESO 2 in Esophageal Pathologies https://ClinicalTrials.gov/show/NCT00885469 Completed Medtronic - MITG 2009-03-31
NCT00844077 Preliminary Longitudinal Validation of Biomarkers Predictive of Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00844077 Completed University of Michigan 2011-04-30
NCT02198976 Australian Barrett’s Cohort With Dysplasia and Early Cancer Study https://ClinicalTrials.gov/show/NCT02198976 Recruiting Western Sydney Local Health District 2020-04-30
NCT00747448 CryoSpray Ablation (TM) GI Patient Registry https://ClinicalTrials.gov/show/NCT00747448 Completed CSA Medical, Inc. 2013-06-30
NCT00590239 Barrett’s Esophagus Related Neoplasia (BERN) Project https://ClinicalTrials.gov/show/NCT00590239 Recruiting Midwest Biomedical Research Foundation 2021-11-30
NCT00588575 Ramanspectroscopy in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00588575 Completed Mayo Clinic 2007-05-31
NCT00587652 Methylene Blue Chromoendoscopy in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00587652 Completed Mayo Clinic 2009-12-31
NCT00587314 The Effect of Ablation Therapy on Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00587314 Enrolling by invitation Mayo Clinic 2020-01-31
NCT00587184 Confocal Microscopy in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00587184 Completed Mayo Clinic 2013-02-28
NCT00586989 Endoscopic Tri-Modal Imaging in Patients With Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00586989 Completed Mayo Clinic 2010-02-28
NCT00586872 Endoscopic Mucosal Resection (EMR) in Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00586872 Enrolling by invitation Mayo Clinic 2025-10-31
NCT00574327 Progression of Gastroesophageal Reflux Disease and Barrett’s Esophagus and the Creation of a Barrett’s Registry https://ClinicalTrials.gov/show/NCT00574327 Recruiting Midwest Biomedical Research Foundation 2023-10-31
NCT00513331 Barrett’s Esophagus & Gastroesophageal Reflux Disease https://ClinicalTrials.gov/show/NCT00513331 Completed Valley Health System 2013-12-31
NCT00445653 Risk Factors for Barrett’s Esophagus in Patients With BE, Gastroesophageal Reflux, or Gastrointestinal Bleeding https://ClinicalTrials.gov/show/NCT00445653 Completed Massachusetts General Hospital 2013-03-31
NCT00431756 Novel Biomarkers in the Neoplastic Progression of Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00431756 Active, not recruiting Johns Hopkins University 2022-06-30
NCT00288119 Genetic Determinants of Barrett’s Esophagus and Esophageal Adenocarcinoma https://ClinicalTrials.gov/show/NCT00288119 Recruiting University Hospitals Cleveland Medical Center 2022-04-30
NCT00081354 Early Detection of Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT00081354 Completed National Institutes of Health Clinical Center (CC) 2013-01-01

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT02988934 The WATS3D (Wide Area Transepithelial Sample Biopsy With 3-Dimensional Computer-Assisted Analysis) U.S. Registry https://ClinicalTrials.gov/show/NCT02988934 Recruiting CDx Diagnostics 2026-04-30
NCT02793479 Radiofrequency Ablation in Patients With Barrett’s Esophagus https://ClinicalTrials.gov/show/NCT02793479 Recruiting Austrian Society Of Surgical Oncology 2020-12-31
NCT02583087 ESD for the Treatment of Early Barrett’s Neoplasia https://ClinicalTrials.gov/show/NCT02583087 Recruiting Hôpital Cochin 2019-04-30
NCT02482701 The Captivator EMR Registry https://ClinicalTrials.gov/show/NCT02482701 Completed Boston Scientific Corporation 2017-05-31
NCT01802203 trūFreeze® Spray Cryotherapy Patient Registry https://ClinicalTrials.gov/show/NCT01802203 Active, not recruiting US Endoscopy Group Inc. 2021-08-31
NCT01776346 Barrett’s Esophagus Patient Registry https://ClinicalTrials.gov/show/NCT01776346 Recruiting Massachusetts General Hospital 2021-12-31
NCT04312633 Clinical Utility of WATS3D: A 5-Year Prospective Study https://ClinicalTrials.gov/show/NCT04312633 Recruiting CDx Diagnostics 2025-04-01
NCT03853772 The Johns Hopkins Heartburn Center Registry https://ClinicalTrials.gov/show/NCT03853772 Enrolling by invitation Johns Hopkins University 2025-12-31